Breast Cancer Case Study - Physiopedia

 

case study of breast cancer

Jan 29,  · Case study breast cancer. Cases in which tumors shrink in response to tamoxifen withdrawal (as well as withdrawal of pharmacologic doses of estrogens) have been reported.• Endogenous estrogen formation may be blocked by analogues of luteinizing hormone– releasing hormone in premenopausal women. Ms. Connolly was referred to a medical oncologist and a radiotherapist, and her case was discussed at the bi-monthly Breast Cancer Tumor Board. A course to include neo-adjuvant chemotherapy followed by surgery and postoperative radiation therapy was chosen. Case Studies: Breast Cancer Expert physicians provide insight on managing oncology-based patient cases that highlight the use of novel agents in clinical practice. SORT BY: A-Z Recent.


Case Studies: Triple-Negative Breast Cancer: Case 1


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Embeds 0 No embeds. No notes for slide. Case study breast cancer 1. It was movable and non-tender. No consult was done, case study of breast cancer. She noted gradual enlargement of the same mass but was non- tender. One month PTC, she noted skin dimpling on her right breast.

Persistence of the above symptoms with now accompanying tenderness on the right breast prompted her to seek consult. But ifbreast cancer is caught early, your chances ofsurvival are very good, case study of breast cancer. And why?

For some nonpalpable lesions, ultrasound may be helpful either to identify cysts or to guide biopsy. In patient. Resection margins are negative for tumor. Although breast cancer in men is unusual, unilateral lesions should be evaluated in the same manner as in women, with the recognition that gynecomastia in men can sometimes begin unilaterally and is often asymmetri 7.

Algorithms have been developed to enhance the likelihood of diagnosing breast cancer and reduce the frequency of unnecessary biopsy 8. All regional lymph node groups should be examined, and any lesions should be measured. Lesions with certain features are more likely to be cancerous hard, irregular, tethered or fixed, or painless lesions. Palpable lesions require additional diagnostic procedures including biopsy.

Days 5—7 of the cycle are the best time for breast examination. What is your management plan for the patient? Chemotherapy is used to maximize distant disease-free survival, whereas radiation therapy is used to maximize local-regional disease-free survival. In selected patients with stage IIIA cancer, neoadjuvant preoperative chemotherapy can reduce the size of the primary cancer and permit breast-conserving surgery.

While breast conservation is associated with a possibility of recurrence in the breast, case study of breast cancer, year survival is at least as good as that after more radical surgery.

Since radiation therapy can also reduce the rate of local or regional recurrence, it should be strongly considered following mastectomy for women with high-risk primary case study of breast cancer i. However, these groups probably do not account for more than one-third of patients who are treated with mastectomy.

Thus, a great many women still undergo mastectomy who could safely avoid this procedure and probably would if appropriately counseled Both axillary lymph node involvement andinvolvement of vascular or lymphatic channelsby metastatic tumor in the breast are associatedwith a higher risk of relapse in the breast but arenot contraindications to breast-conservingtreatment.

Selection of appropriate adjuvant chemotherapy or hormone therapy is highly controversial in some situations. Meta-analyses have helped to define broad limits for therapy but do not help in choosing optimal regimens or in choosing a regimen for certain subgroups of patients. A summary of recommendations is shown in Table In general, premenopausal women for whom any form of adjuvant systemic therapy is indicated should receive multidrug chemotherapy Multiple combinations of these agents have been found to improve response rates somewhat, but they have had little effect on duration of response or survival.

The choice among multidrug combinations frequently depends on whether adjuvant chemotherapy was administered and, if so, what type. While patients treated with adjuvant regimens such as cyclophosphamide, methotrexate, and fluorouracil CMF regimens may subsequently respond to the same combination in the metastatic disease setting, most oncologists use drugs to which the patients have not been previously exposed. Once patients have progressed after combination drug therapy, it is most common to treat them with single agents.

Given the significant toxicity of most drugs, the use of a single effective agent will minimize toxicity by sparing the patient exposure to drugs that would be of little value. No method to select the drugs most efficacious for a given patient has been demonstrated to be useful. However, the choice has to be balanced with individual needs.

One randomized study has suggested docetaxel may be superior to paclitaxel. A nanoparticle formulation of paclitaxel abraxane has also shown promise. The magnitude of the survival extension is modest in patients with metastatic disease. Similarly, the use of bevacizumab avastin case study of breast cancer improved the response rate and response duration to paclitaxel.

Objective responses in previously treated patients may also be seen with gemcitabine, capecitabine, navelbine, and oral etoposide Pathologic stage combines the findings from pathologic examination of the resected primary breast cancer and axillary or other regional lymph nodes This information plays a critical role in treatment planning.

With too many receptors, the cells receive too many growth signals. This marker may be used to determine if the breast cancer has traveled to other areas of the body. High circulating tumor cell counts may indicate that the cancer is growing. The CellSearch test has been approved by the U. Food and Drug Administration to monitor circulating tumor cells in women diagnosed with metastatic breast cancer. Risk factor biomarkers are those associated with increased cancer risk.

For most women, the need for adjuvant therapy can be readily defined on this basis alone. In the absence of lymph node involvement, involvement of microvessels either capillaries or lymphatic channels in tumors is nearly equivalent to lymph node involvement Tumors that lack either or both of these receptors are more likely to recur than tumors that have them.

S-phase analysis using flow cytometry is the most accurate measure. Tumors with a poor nuclear grade have a higher risk of recurrence than tumors with a good nuclear grade.

Particular interest has centered on erbB2 overexpression as measured by histochemistry or case study of breast cancer fluorescence in situ hybridization. The presence of more microvessels in a tumor, case study of breast cancer, particularly when localized in so- called "hot spots," is associated with a worse prognosis.

This may assume even greater significance in light of blood vessel—targeting therapies such as bevacizumab avastin. Although no randomized study of BSE has ever case study of breast cancer any improvement in survival, its major benefit is identification of tumors appropriate for conservative local therapy. Both primary and metastatic breast cancer may retain this phenotype. The best means of ascertaining whether a breast cancer is hormone-dependent is through analysis of estrogen and progesterone receptor levels on the tumor.

In most patients, the initial endocrine therapy should be an aromatase inhibitor rather than tamoxifen. Cases in which tumors shrink in response to tamoxifen withdrawal as well as withdrawal of pharmacologic doses of estrogens have been reported. You just clipped your first slide! Clipping is a handy way to collect important slides you want to go case study of breast cancer to later.

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Case Studies: Breast Cancer

 

case study of breast cancer

 

Ms. Connolly was referred to a medical oncologist and a radiotherapist, and her case was discussed at the bi-monthly Breast Cancer Tumor Board. A course to include neo-adjuvant chemotherapy followed by surgery and postoperative radiation therapy was chosen. Breast Cancer Case Study. Nausea & Vomiting – anti-emetic drug, eat and drink slowly, drinking enough fluids Mouth sores (Muscovites) – ETC anesthetics, ice Chips or popsicles, gargling Diarrhea – drink plenty of fluids, high-protein foods, cooked vegetables, fresh fruits without the skin Hair loss – wear some kind of head covering (scarf, turban. Case Studies: Breast Cancer Expert physicians provide insight on managing oncology-based patient cases that highlight the use of novel agents in clinical practice. SORT BY: A-Z Recent.